- Experimental Design - We provide guidance based on years of biotech and pharma experience
to ensure that your experiments are using the best and most appropriate technology to answer your scientific questions and
are powered to provide maximal impact.
- Computational Analysis - We provide complete computational analyses including:
- Sequence analysis including Next Generation sequence analysis
Whether you need standard sequence comparisons and motif hunting, or assembly and calculating expression levels
from your Illumina or 454 Next Gen Sequencing data, we have the capability to handle it. We leverage Amazon's
compute cloud to obtain scalability thus reducing your overhead and costs.
- Expression profiling analysis
We have a long history analysing Affymetrix microarray
and Illumina bead data.
- Gene set enrichment analysis
In addition to the standard GSEA and the Broad GSEA, we have
developed a semi-quantitative method that provides an estimate of how much cellular processes increase or decrease between
expression datasets.
- Pathway analysis including development of novel pathways
We are the leaders in using Ariadne's Pathway Studio and Ingenuity's Pathway Analysis to build de novo
pathways based on causal inferencing on expression and high-throughput screening data.
- Meta-genomics analysis - including analyses tolerant of missing data
Target ranking based on gene response across multiple types of data
We use a multiple parameter optimisation method that ranks genes based on their response across disparate
data types and is tolerant of missing data. The top-ranked genes are then analysed with pathway and functional
analyses. This method has been successfully applied to multiple
therapeutic areas and was showcased at the Society for Neuroscience meeting, Nov. 2011.
- Biomarker identification
We use de novo pathway development based on causal inferencing to identify measurable markers that are
causally associated with your target. This gives you a much higher confidence that you will be able to detect
if your compound is hitting your target.
- Deep Biological Interpretation - We work with you to gain a deep understanding of the cellular processes
and pathways affected in your experiments, and the genes involved in them
- Infrastructure - We can develop and support your bioinformatics software and databases. Whether you need a complete
analysis environment developed or simply have a collection of tools and datasets that need to be managed, we can handle it.
- Software Usability Testing - We have a long history of working closely with companies to ensure that their software
is easy to use and matches bench or computational scientists' needs. We help companies develop products that users
actually want to use.
- Contact us today to start a collaboration